1. Clinical research must conform to the moral and scientific principles that
justify medical research, and should be based on laboratory and animal
experiments or other scientifically established facts.
2. Clinical research should be conducted only by scientifically qualified persons
and under the supervision of a qualified medical man.
3. Clinical research cannot legitimately be carried out unless the importance of
the objective is in proportion to the inherent risk to the subject.
4. Every clinical research project should be preceded by careful assessment of
inherent risks in comparison to foreseeable benefits to the subject or to others.
5. Special caution should be exercised by the doctor in performing clinical
research in which the personality of the subject is liable to be altered by drugs
or experimental procedure.