III. Nontherapeutic Clinical Research
1. In the purely scientific application of clinical research carried out on a human being it is the duty of the doctor to remain the protector of the life and health of that person on whom clinical research is being carried out.
2. The nature, the purpose, and the risk of clinical research must be explained to the subject by the doctor.
3a. Clinical research on a human being cannot be undertaken without his free consent, after he has been fully informed; if he is legally incompetent the consent of the legal guardian should be procured.
3b. The subject of clinical research should be in such a mental, physical, and legal state as to be able to exercise fully his power of choice.
3c. Consent should as a rule be obtained in writing. However, the responsibility for clinical research always remains with the research worker; it never falls on the subject, even after consent is obtained.
4a. The investigator must respect the right of each individual to safeguard his personal integrity, especially if the subject is in a dependent relationship to the investigator.
4b. At any time during the course of clinical research the subject or his guardian should be free to withdraw permission for research to be continued. The investigator of the investigating team should discontinue the research if in his or their judgment it may, if continued, be harmful to the individual.