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CDC Smallpox Plan, archived as of 28 Feb 2010. Original Link

Smallpox Response Plan and Guidelines (Version 3.0)
Archive - Use Only For Research Purposes

On this page:

November 26, 2002 - The CDC Smallpox Response Plan and Guidelines (Guides A-F plus Annex files 1-8) were last updated on September 23, 2002. On November 26, 2002, all of the forms within Guide A were updated to Version 3.0. (note 1)

This document outlines the public health strategies that would guide the public health response to a smallpox emergency and many of the federal, state, and local public health activities that must be undertaken in a smallpox outbreak.

PDFAdobe Acrobat Reader
Cover Page (includes contact information) view
(72 KB/2 pages)
Table of Contents view
(112 KB/2 pages)
Executive Summary plus Sections A through F (Includes: criteria for implementation of CDC smallpox response plan; notification procedures for suspected smallpox cases; CDC and state/local responsibilities and action in the event of a smallpox outbreak; vaccine mobilization and deployment; and CDC personnel mobilization and deployment, etc.) view
(237 KB/10 pages)
Draft Guide A—Smallpox Surveillance and Case Reporting; Contact Identification, Tracing, Vaccination, and Surveillance; and Epidemiologic Investigation
(Includes: pre-event rash surveillance; smallpox clinical case description and differential diagnosis; smallpox case definitions and classifications; post-event response epidemiological investigation; post-event surveillance; contact identification, tracing and surveillance; description of Smallpox Post-Event Surveillance Forms, etc.) (note 2)
Draft Guide A
(Case definition [section III] was updated on Dec 31, 2003)
(589 KB/31 pages)
Overview of forms view
(126 KB/3 pages)
Draft Appendix 16
(Includes: Using forms and worksheets for contact identification, tracing, vaccination, and surveillance)
(119 KB/5 pages)
Complete Workflow with Forms view
(102 KB/5 pages)
Form 1 Post-Event Surveillance Version 3.0
Please note the following major changes in Form 1: Laboratory confirmation, and smallpox case classifications and clinical types
(148 KB/2 pages)
(61 KB/8 pages)
Form 2a Case Travel/Activity Worksheet—Infectious Period Version 3.0 view
(80 KB/1 page)
(167 KB/4 pages)
Form 2b Primary Contact/Site Worksheet Version 3.0
Please note the following major changes in Form 2b: contact priority codes 1-5
(101 KB/1 page)
(167 KB/4 pages)
Form 2c Contact Transportation Worksheet—Infectious Period Version 3.0 view
(110 KB/1 page)
(167 KB/4 pages)
Form 2d Contact Tracing Version 3.0 view
(399 KB/1 page)
(163 KB/5 pages)
Form 2e Case Household and Primary Contact Surveillance Version 3.0 Please note the following major changes in Form 2e: New form for primary contact surveillance view
(117 KB/1 page)
(125 KB/2 pages)
Form 2f Case Primary Contact's Household Members Surveillance Version 3.0 Please note the following major changes in Form 2f: New form for secondary contact surveillance view
(71 KB/1 page)
(98 KB/2 pages)
Form 3a Case Exposure Investigation Version 3.0 view
(205 KB/2 pages)
(131 KB/4 pages)


Form 3b Case Travel/Activity Worksheet—Exposure Period Version 3.0 view
(95 KB/1 page) 
(131 KB/4 pages)
Form 3c Case Transportation Worksheet—Exposure Period Version 3.0 view
(110 KB/1 page)
(131 KB/4 pages) 
Guide B—Vaccination Guidelines for State and Local Health Agencies
(Includes: vaccination guidelines, vaccination strategies, indications for vaccination, contraindications for vaccination, reconstitution, administration, and storage of vaccine, recognition of expected vaccine reactions/take, recognition of adverse reactions, indications and guidelines for VIG administration, etc.) 
Part 1 view
(145 KB/7 pages)
Part 2 view
(267 KB/9 pages) 
Part 3 view
(427 KB/5 pages)
Guide C—Infection Control Measures for Healthcare and Community Settings and Quarantine Guidelines
Part 1
Infection Control Measures for Healthcare and Community Settings
(236 KB/14 pages)
Part 2
Quarantine Guidelines
(174 KB/8 pages)
Guide D—Specimen Collection and Transport Guidelines
(Includes: specimen collection supply list; procedure for patients with vesicles or pustules; procedure for patients with scab lesions; autopsy specimens; packing and labeling of specimens, etc.)
Specimen Collection and Transport Guidelines view
(239 KB/12 pages)
Guide E—Communications Plans and Activities
(Includes: overall communication plan purpose; overall smallpox plan objectives; guiding principles; pre-event and post-event activities, etc.)
Communications Plans & Activities view
(581 KB/29 pages)
Guide F—Environmental Control of Smallpox Virus
(Includes: use of current medical decontamination protocols utilizing low- to intermediate-level chemical germicides or EPA-registered detergent disinfectants for the cleaning of surfaces potentially contaminated with smallpox virus)
Environmental Control of Smallpox Virus view
(227 KB/10 pages)
Annex Files (1-10)
Annex 1—Overview of Smallpox and Clinical Presentations, and Medical Care of Smallpox Patient
(19 pages total, due to number of images broken into 3 sections)
(820 KB/pages 1-9)
(183 KB/pages 10-16)
(261 KB/pages 17-19)
Annex 2—General Guidelines for Smallpox Vaccination Clinics view
(146 KB/24 pages)
Annex 3—Guidelines for Large Scale Smallpox Vaccination Clinics
(Logistical Considerations and Guidance for State and Local Planning for Emergency, Large-Scale, Voluntary Administration of Smallpox Vaccine in Response to a Smallpox Outbreak. Also provides details on all aspects of immunization clinic operations and staffing with an example of a model smallpox vaccination clinic.)
(953 KB/48 pages)
Annex 4—Vaccine Adverse-Event Reporting
(Vaccine Safety: Monitoring and Reporting of Adverse Events Following Smallpox Vaccination)
(304 KB/19 pages)
Annex 5—Suggested Pre-Event Planning Activities for State & Local Health Authorities view
(492 KB/28 pages)
Generalized Vesicular or Pustular Rash Illness Protocol color view
(78 KB/1 page)
Generalized Vesicular or Pustular Rash Illness Protocol black & white view
(129 KB/1 page)
Annex 6—Data Management
Part 1—Smallpox Response System Requirements view
(315 KB/9 pages)
Part 2—Data Exchange Format Requirements view
(763 KB/21 pages)
Part 3—Smallpox Post-Event Response Outbreak Management System (OMS) view
(874 KB/10 pages)
Annex 7—Forms in development view
(25 KB/2 pages)
Annex 8—Checklists for State/Local/CDC Personnel Actions in a Smallpox Emergency view
(292 KB/7 pages)
Annex 9 Coming soon  
Annex 10 (formerly Annex 6)—Glossary of Abbreviations and Smallpox References view
(90 KB/3 pages)
1.  About the Forms in This Response Plan
OMB NO. 0920-0008
Exp. Date 06/2003
Public reporting burden of this collection of information is estimated to average __ minutes per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. An agency may not conduct or sponsor, and a person is not required to respond to a collection of information unless it displays a currently valid OMB control number. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to CDC/ATSDR Reports Clearance Officer; 1600 Clifton Road NE, MS D-24, Atlanta, Georgia 30333; ATTN: PRA (0920-0008).
2.  About the Forms in Guide A (below): These forms are draft versions and are available as examples of the types of information that should be collected. Planning efforts including large-scale form replication or database development should take this into consideration as these draft versions are subject to change. Until finalized versions are available, these forms may be utilized for emergency use if needed. As the forms are updated and/or finalized, they will be posted to this website and noted as such. The smallpox post-event draft forms (Version 3.0) are part of a comprehensive, integrated data management and analysis system currently under development. Any changes to these draft forms would affect the response team’s capability to efficiently and effectively collect event data. Therefore, they are only available in .pdf format that should not be modified.



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