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Brown v. American Home Products Corporation Diet Drugs, No. 99-20593 (E.D.Pa. 08/28/2000)

Brief of Brown v. American Home Products Corporation Diet Drugs, No. 99-20593 (E.D.Pa. 08-28-2000)

[1]      IN THE UNITED STATES DISTRICT COURT FOR THE EASTERN DISTRICT OF PENNSYLVANIA

[2]      CIVIL ACTION No. 99-20593

[3]      2000.EPA.0042649 <http://www.versuslaw.com>

[4]      August 28, 2000

[5]      IN RE (PHENTERMINE, FENFLURAMINE, DEXFENFLURAMINE) PRODUCTS LIABILITY LITIGATION
SHEILA BROWN, ET AL.
v.
AMERICAN HOME PRODUCTS CORPORATION DIET DRUGS

[6]      The opinion of the court was delivered by: Bechtle, J.

[7]      THIS DOCUMENT RELATES TO MDL DOCKET NO. 1203

[8]      MEMORANDUM AND PRETRIAL ORDER NO. 1415

[9]      Presently before the court is the Joint Motion of the Class Representatives and American Home Products Corporation ("AHP") for an order certifying and approving the nationwide settlement class embodied in the Settlement Agreement entered into between the parties on November 19, 1999. For the reasons set forth below, the court will grant the motion and will certify the class and approve the settlement pursuant to Federal Rule of Civil Procedure 23. The court's findings of fact and conclusions of law are as follows.

[10]     I. BACKGROUND

[11]     A. The Diet Drug Litigation

[12]     This litigation involves claims regarding the health effects of two related prescription drugs--fenfluramine and dexfenfluramine. Fenfluramine is an appetite suppressant that affects blood levels of the neurotransmitter, serotonin. Dexfenfluramine, the "d-isomer" of fenfluramine, is chemically related to fenfluramine and acts as an appetite suppressant by stimulating the release of serotonin from nerve cells in the brain and by reducing the reuptake of the released serotonin. In 1973, The United States Food and Drug Administration ("FDA") approved A.H. Robins, Inc.'s new drug application to market fenfluramine in the United States. (Ex. P-180.)

[13]     Before 1989, A.H. Robins, Inc. was responsible for the marketing, sale and labeling of fenfluramine in the United States. In 1989, AHP acquired A.H. Robins. Following the acquisition, fenfluramine was marketed by AHP under the trade name "Pondimin." Between December 1989 and September 15, 1997, AHP was the only company to market fenfluramine in the United States and had the exclusive responsibility for its regulatory compliance, adverse event reporting, safety surveillance and labeling.

[14]     Sales of Pondimin were relatively flat until 1992. In 1992, a series of articles by Michael Weintraub, M.D., were published in the Journal of Clinical Pharmacology and Therapy, in which Dr. Weintraub advocated the use of fenfluramine together with the drug phentermine for weight loss management without the adverse side effects associated with the use of fenfluramine alone. This regimen popularly became known as "Fen-Phen." With the introduction of "Fen-Phen" therapy to the market place, sales of Pondimin skyrocketed. From January 1995 to mid-September 1997, approximately 4,000,000 persons in the United States took the drug Pondimin. (Tr. 5/2/00 at 26-27; Ex. P-183 at 29 of 33; Ex. P-182 at 5 of 13.)

[15]     Dexfenfluramine, the chemical cousin of Pondimin, was developed by Les Laboratories Servier S.A. ("LLS") in France. The drug afforded the same anorexic effects as Pondimin without the need to add phentermine to ameliorate adverse side effects. Before 1994, the Lederle Division of American Cyanamid Company had the right, together with Interneuron Pharmaceuticals, Inc., to develop and promote dexfenfluramine in the United States under the trade name "Redux." In 1994, AHP acquired American Cyanamid. Following that acquisition, responsibility for the development and promotion of Redux in the United States in conjunction with Interneuron was assumed by AHP. Interneuron received approval to market Redux in the United States in mid-1996. As with Pondimin, sales of Redux were brisk. From June 1996 through September 15, 1997, two million people in this country took Redux. (Tr. 5/2/00 at 28; Ex. P-183 at 29 of 33; Ex. P-182 at 5 of 13.)

[16]     The distribution of Redux users by age and sex was virtually the same as that for Pondimin. (Ex. P-94 at 3 of 41; Ex. P-53 at 9 of 54.) Most of the individuals who took the diet drugs Pondimin and Redux were middle aged women. (Ex. P-94 at 3 of 41; Ex. P-53 at 9 of 44.)

[17]     From the viewpoint of plaintiffs' counsel, the evidence reveals that before Pondimin and Redux were withdrawn from the market in 1997, which is discussed infra, AHP received considerable information from a number of sources that both drugs could cause damage to the valves in the heart leading to valvular regurgitation. This information consisted of reports in the medical literature, reports from animal studies, reports concerning heart valve damage in patients taking drugs with similar effects on serotonin metabolism, adverse event reports and reports from a doctor commissioned to analyze certain facts for Interneuron. According to plaintiffs, notwithstanding this information, during the period of time AHP marketed dexfenfluramine and fenfluramine, it failed to investigate these reports, to look at whether or not the drugs were cardiotoxic or to label the drugs as being potentially harmful to the heart valves.

[18]     In response, AHP has vigorously contested the plaintiffs' interpretation of these events, noting that much of this information was submitted to the FDA for its own analysis; that none of the doctors or scientists who reported on Pondimin or Redux, either in the published literature or in the adverse event reports, concluded that either product caused any valvular disease; and that, given the substantial prevalence of such valvular disease in the general population, it was not possible to conclude, on the basis of these reports, that its products caused disease.

[19]     In March 1997, researchers at the Mayo Clinic in Rochester, Minnesota began observing an association between the use of fenfluramine and/or dexfenfluramine and a particular type of valvular heart disease. Eventually, the Mayo Clinic researchers observed this unusual form of valvular heart disease in 24 women who had used fenfluramine in combination with phentermine. (Ex. P-95 ¶ 39; Tr. 5/2/00 at 29; Ex. P-113; Ex. P-181; Ex. P-182.) The findings of the Mayo researchers were first brought to the attention of the public in a July 8, 1997 press release and were eventually published on August 28, 1997, in the New England Journal of Medicine. (Exs. P-181 & P-113.)

[20]     On July 8, 1997, the FDA issued a public health advisory, followed by letters to 700,000 physicians requesting information about similar patients. Based on information the FDA received in response, the FDA requested the withdrawal of fenfluramine and dexfenfluramine from the U.S. market. On September 15, 1997, AHP and the FDA announced that there would be no further sales of Pondimin and Redux in the United States. Subsequently, the causal relationship between valvular heart disease and the use of dexfenfluramine and fenfluramine was investigated and confirmed in three epidemiological studies published in the New England Journal of Medicine in September 1998. (Exs. P-127 (Jick), P-130 (Khan) & P-170 (Weissman).)

[21]     A wave of litigation followed. As of the time that class notice issued in this matter, approximately 18,000 individuals who used Pondimin or Redux filed lawsuits against AHP. (Tr. 5/2/00 at 196-97.) Many of these lawsuits involved actions in which individuals sought to recover for personal injuries, primarily valvular heart disease, that they sustained as a result of using Pondimin or Redux. In addition, over one hundred plaintiffs instituted class actions in which they sought either: (1) to create an equitable fund to provide medical screening services to patients who had used Pondimin and/or Redux for varying periods of time to determine if they had asymptomatic valvular heart disease; and/or (2) to recover the amounts expended by consumers to purchase Pondimin and/or Redux or to obtain echocardiograms as a consequence of exposure to these drugs; and/or (3) to recover personal injury damages on behalf of classes of persons who took Pondimin and/or Redux. (Tr. 5/2/00 at 20-21 & 36-39.)

[22]     To the extent that these actions were filed in the federal judicial system, the Judicial Panel for Multidistrict Litigation entered an order transferring all of the actions to the United States District Court for the Eastern District of Pennsylvania for coordinated and/or consolidated pretrial proceedings under MDL Docket No. 1203. As the transferee court, this court entered an order creating and appointing a Plaintiffs' Management Committee ("PMC") to oversee the conduct of the coordinated/consolidated pretrial proceedings on behalf of the plaintiffs. See Pretrial Order No. 6. *fn1

[23]     By the summer of 1999, a combination of state court and federal court decisions certified classes to pursue some form of relief on behalf of those persons who had used AHP's diet drugs. See Pretrial Order No. 865, Jeffers v. American Home Prods. Corp., C.A. No. 98-CV-20626 (certifying nationwide medical monitoring class in MDL court); Burch, et al. v. American Home Prods. Corp., C.A. No. 97-C-204(1-11) (certifying medical monitoring and personal injury class in West Virginia); Rhyne v. American Home Prods. Corp., 98 CH 409 (certifying medical monitoring class in Illinois); Vadino, et al. v. American Home Prods. Corp., Docket No. MID-L-425-98 (certifying class seeking medical monitoring and damages for unfair and deceptive trade practices in New Jersey); In re: New York Diet Drug Litig., Index No. 700000/98 (certifying medical monitoring class in New York); In re: Pennsylvania Diet Drug Litig., Master Docket No. 9709-3162 (CCP, Phila.) (certifying medical monitoring class in Pennsylvania); Earthman v. American Home Prods. Corp., No. 97-10-03970 CV, (certifying medical monitoring class in Texas); St. John v. American Home Prods. Corp., 97-2-06368-4 (certifying medical monitoring class in Washington).

[24]     By the summer of 1999, the parties in both the state litigation and the federal MDL litigation had virtually completed discovery with respect to AHP's conduct. (Tr. 5/2/00 at 21-23.) More than 6,000,000 documents were produced by AHP and carefully reviewed, analyzed and collated by the plaintiffs. Id. In the federal litigation, the PMC took nearly 100 depositions of present and former employees of AHP, Interneuron, the FDA and other third parties. (Tr. 5/2/00 at 21-23; Ex. P-1000.) The state court plaintiffs conducted similar deposition discovery, deposing many of the individuals who were the subject of the MDL discovery effort.

[25]     In both the MDL litigation and the state court litigation, the plaintiffs consulted with experts in various subjects related to the litigation, including primary pulmonary hypertension, cardioepidemiology, cardiology, cardio-thoracic surgery, clinical pharmacology, cardiopathology, economics, and the like. These experts revealed their opinions in Rule 26 disclosures and were subject to both discovery depositions and, in many cases, depositions designed to preserve their testimony for use at trial. Thus, by the summer of 1999, the plaintiffs had a thorough understanding of the facts underlying the question of AHP's liability to those individuals and classes of individuals who had used Pondimin and Redux, as well as a firm grasp of the relevant scientific principles pertaining to liability, injury and causation in these cases. Also, by the summer of 1999, cases against AHP had begun to go to trial. The most significant of these was the New Jersey Vadino case in which New Jersey Superior Court Judge Marina Corodemus presided over a trial of the class claims certified in that action.

[26]     B. The Settlement Negotiations

[27]     In late April 1999, AHP invited representatives of the varying constituencies of state and federal plaintiffs to begin negotiations with it for a "global resolution" of the Diet Drug Litigation. In response to that invitation, a negotiating coalition was formed among representatives of the PMC in the MDL court and representatives of the plaintiffs in state courts with pending certified class actions. (Tr. 5/2/00 at 40-42; AHP Ex. 629 at 65-66 and 71; AHP Ex. 628 at 60-61.)

[28]     The plaintiffs' negotiating coalition presented its initial proposal to AHP in the form of a "term sheet" on June 1, 1999. (Tr. 5/2/00 at 47-48.) AHP responded to that proposal with a counter-proposal on June 28, 1999. (Tr. 5/2/00 at 48-49.) Thereafter, intense, adversarial and arm's-length negotiations ensued for more than four months, during which time: Class Counsel in New Jersey prepared for and began the medical monitoring class action trial before Judge Corodemus; cases in Texas proceeded to trial and, in one case, to a substantial verdict against AHP; and individual cases were poised for remand for trial in the MDL 1203 proceedings. (Tr. 5/2/00 at 39; AHP Ex. 628 at 35.) Altogether, members of the negotiating coalition and representatives of AHP participated in approximately 73 negotiating sessions, over a period extending from April through November 1999. (Tr. 5/2/00 at 59.)

[29]     Those negotiating the settlement on behalf of the plaintiffs had no understandings, or even negotiations with AHP with respect to any of their individual cases. (Tr. 5/2/00 at 41 & 58-61.) The terms and conditions of the Settlement Agreement were the product of a bargaining process between the parties involving separately negotiating or "building up" the settlement's benefits and obligations in contrast to a process of negotiating a lump sum dollar amount that would then be allocated or "broken down" among class members. The negotiators proceeded by negotiating the types of screening and compensation benefits to be made available to class members and the eligibility for those benefits. Only when those benefits and compensation amounts had been essentially resolved did the parties negotiate the maximum monetary commitment that AHP would incur in providing those benefits. (Tr. 5/2/00 at 59.) During the negotiations, AHP never offered, and the plaintiffs never requested, payment of a lump sum to resolve the claims of class members. To the contrary, the negotiations were devoted to working out a structure that would appropriately resolve the claims of all individuals who took Pondimin and/or Redux. Only when that structure was agreed upon did the parties determine the amount of money that would be necessary to fund the structure. (Tr. 5/2/00 at 58-61; Tr. 5/3/00 at 210-211; AHP Ex. 628 at 100.) Each of the major benefit features of the settlement was the subject of a separate, independent and, at times, heated negotiation process. Importantly, under the settlement process that was employed, there was no intra-class trading off of benefits. That is, one benefit of the settlement did not have to be reduced in exchange for the creation or increase of another benefit. (Tr. 5/2/00 at 42-59, 154-61 & 166-67; AHP Ex. 628 at 110-12.) Moreover, the subject of attorneys' fees was not discussed until the end of the negotiations and then only to limit the award of fees that might otherwise be payable, subject to appropriate limitations for the benefit of the class. (Tr. 5/2/00 at 88; AHP Ex. 629 at 208-39.)

[30]     Throughout the negotiations, the members of the negotiating coalition were willing to litigate their clients' claims in the event that negotiations broke down. (Tr. 5/2/00 at 49, 60-61.) Members of the negotiating coalition were armed with substantial leverage in their negotiations with AHP as a result of plaintiffs' willingness and ability to litigate their claims should negotiations fail. This leverage derived from, among other things, the pendency of the Jeffers action brought by the PMC in the MDL court, several certified state court medical monitoring class actions in which the negotiators or their constituencies were participating, individual diet drugs cases pending in the MDL proceedings and in state courts seeking compensation for personal injury, and the trial of the Vadino medical monitoring case which was underway when the negotiations were taking place.

[31]     By October 7, 1999, the parties had reached an understanding on the principal terms of the settlement, embodied in a Memorandum of Understanding ("MOU"). (Ex. P-49.) After the execution of the MOU, the parties continued with round-the-clock negotiations with respect to the terms left open by the MOU. (Tr. 5/2/00 at 57.) The court also ordered the PMC to make periodic reports to it on fifteen-day intervals concerning the status of the Settlement Agreement. The court was kept apprised of the status of the negotiations. See Pretrial Order No. 929.

[32]     Ultimately, on November 18, 1999, the parties executed a Nationwide Class Action Settlement Agreement with AHP. (Exs. P-3 through P-30.) The Court granted preliminary approval of the Settlement Agreement on November 23, 1999 and set May 1, 2000 as the date to commence a Fairness Hearing regarding the Settlement Agreement. See Pretrial Order No. 997. The Agreement has since been subject to four amendments. (First Amendment, Ex. P-31; Second Amendment with Exhibits, Exs. P-32 through P-48; Third Amendment, Ex. P-47; and Fourth Amendment, Ex. P-278.)

[33]     C. Procedural Background and Fairness Hearing

[34]     On January 28, 2000, the court entered Pretrial Order No. 1071. That order established a "Special Discovery Court" to convene on a weekly basis commencing Wednesday, February 2, 2000 "for the limited and exclusive purpose of promptly administering discovery requirements and resolving discovery disputes applicable to proceedings before the Court regarding consideration of the judicial approval of the nationwide class action Settlement Agreement." Pretrial Order No. 1071 at 1.

[35]     On February 3, 2000, the court entered Pretrial Order No. 1109. That Pretrial Order manifested the court's "intention that an eligible party have the opportunity to conduct, under reasonable terms and conditions: (1) discovery pertinent to the issues to be decided at the Fairness Hearing; or (2) discovery deemed important by the eligible person in order to make the decision whether or not to object to the settlement, appear at the Fairness Hearing to object or provide the Court with written comments without an appearance at the Fairness Hearing." Toward this end, Pretrial Order No. 1109 directed that:

[36]     on or before February 20, 2000 class counsel and the defendant shall file with the Court: (i) a statement identifying all fact witnesses to be called to testify at the Fairness Hearing, together with a brief statement on the anticipated substance of the testimony of each witness; (ii) copies of all documents or other exhibits to be offered into evidence; and (iii) the identities of all expert witnesses to be called together with the information required in Federal Rule of Civil Procedure 26(a)(2)(B). On or before April 10, 2000 any person or party who has fulfilled the requirements of paragraph 17 of PTO No. 997 shall provide to class counsel and the defendant: (i) a statement identifying all fact witnesses to be called to testify at the Fairness Hearing together with a brief statement on the anticipated subject of the testimony of each witness; (ii) copies of all documents or other exhibits to be offered into evidence; and (iii) the identities of all expert witnesses to be called, together with the information required in Federal Rule of Civil Procedure 26(a)(2)(B). Pretrial Order No. 1109.

[37]     On February 10, 2000, the court entered Pretrial Order No. 1116 modifying Pretrial Order No. 1109 as follows:

[38]     PTO No. 1109 is modified to the effect that class proponents shall have until Monday, February 28, 2000, to disclose the names of all their intended Expert Witnesses, provide Curriculum Vitae for each Expert Witness, provide a list of any prior case in which any of the experts have testified, and provide a summary of the expected subject area of each Expert's testimony consistent with Rule 26(a)(2)(B). Also on that date, class counsel shall provide the completed disclosures for at least half of the expert witnesses identified. For any remaining Experts, full disclosures shall be completed on a rolling basis by March 20, 2000. Pretrial Order No. 1116.

[39]     Acting as liaison counsel for the plaintiffs in the above-entitled matter, Arnold Levin, Esq. transmitted copies of each of the above orders to each attorney in the United States known or believed to be representing individuals who are members of the class as defined above.

[40]     The beginning of the Fairness Hearing was adjourned, by one day, to May 2, 2000. At the Fairness Hearing, the proponents of the Settlement Agreement and the persons who objected to the settlement pursuant to the terms of Pretrial Order No. 997 ("the Objectors") had a full and fair opportunity to offer all of the evidence that they wished to tender to the court concerning the proposed nationwide class action Settlement Agreement.

[41]     Class Counsel offered the following witnesses in support of the settlement:

[42]     1. Michael D. Fishbein, Esquire. Mr. Fishbein's testimony concerned the litigation background for the Settlement Agreement, the negotiations leading up to the execution of the Settlement Agreement, and the terms of the Settlement Agreement.

[43]     2. Robyn J. Barst, M.D.. Dr. Barst is one of the leading experts regarding primary pulmonary hypertension. The subject of Dr. Barst's testimony concerned the proper definition of primary pulmonary hypertension under the Settlement Agreement.

[44]     3. Troyen A. Brennan, M.D., J.D.. Dr. Brennan was offered as an expert in the fields of public health and epidemiology.

[45]     4. Professor John C. Coffee, Jr.. Professor Coffee is the Adolf A. Berle Professor of Law at Columbia University Law School. Professor Coffee was offered as an expert in class certification in the mass tort context.

[46]     5. Molly Kuehn Watson. Ms. Watson is a media planning consultant with 14 years of experience. Ms. Watson testified as an expert in media planning as it related to class notice.

[47]     6. Professor Arthur R. Miller. Professor Miller is a professor of law at Harvard Law School. Professor Miller was offered as an expert on issues related to Federal Rule of Civil Procedure 23.

[48]     7. Harvey S. Rosen, Ph.D.. Dr. Rosen was offered as an expert in the field of economics.

[49]     8. Eric D. Caine, M.D.. Dr. Caine was offered as an expert witness in the field of neuropsychiatry, which involves the psychiatric and neuropsychological symptoms and signs of brain diseases.

[50]     9. Dean G. Karalis, M.D., F.A.C.C.. Dr. Karalis was offered as an expert in the field of cardiology, valvular heart disease and echocardiography.

[51]     10. Steven N. Goodman, M.D., M.H.S., Ph.D.. Dr. Goodman was offered as an expert in the design and analysis of epidemiologic and clinical studies, meta-analysis and methods for making inferences from statistical summaries.

[52]     11. Samuel J. Kursh, D.B.A.. Dr. Kursh serves as vice president of the Center for Forensic Economic Studies where his responsibilities include damage modeling and projections in complex litigation.

[53]     12. Kenneth R. Feinberg, Esquire. Mr. Feinberg is an attorney and founder of the Feinberg Group, LLP, headquartered in Washington, D.C. Mr. Feinberg was offered as an expert on the resolution of mass tort litigation, particularly under Federal Rule of Civil Procedure 23.

[54]     13. Professor Sam Dash. Professor Dash is a professor of law at Georgetown University Law Center. Professor Dash was called to testify as an expert in the area of legal ethics, particularly as they apply in the class action context.

[55]     14. Class Counsel also offered other evidence including live testimony by Peter Pakradooni, a Declaration by Deborah A. Hyland, deposition transcripts, and a number of exhibits.

[56]     AHP offered a number of witnesses, subject to cross-examination, on matters relevant to the settlement, including:

[57]     15. Sanjiv Kaul, M.D.. Dr. Kaul is a professor of medicine and the Frances Myers Ball Professor of Cardiology at the University of Virginia where he is director of its Cardiac Imaging Center.

[58]     16. Pravin Shah, M.D.. Dr. Shah is the medical director of the Hoage Heart Institute and professor of medicine at Loma Linda University.

[59]     17. Walter F. Stewart, Ph.D., M.P.H.. Dr. Stewart is adjunct associate professor of epidemiology of Johns Hopkins School of Hygiene and Public Health, former consultant to the EPA, OSHA, National Cancer Institute, and the NIH; and a reviewer for the American Journal for Epidemiology, Epidemiology Review, and the American Journal of Public Health.

[60]     18. Arthur E. Weyman, M.D.. Dr. Weyman is a professor of medicine at Harvard Medical School, director of the Cardiac Ultrasound Laboratory at Massachusetts General Hospital, former chief of cardiology at Massachusetts General, president of the National Board of Echocardiography, former president of the American Society of Echocardiography, author of the text entitled Echocardiography, and is board certified in internal medicine and cardiology.

[61]     19. Professor Peter Schuck. Professor Schuck holds the Simeon E. Baldwin Professorship at Yale Law School. Professor Schuck is a member of the American Law Institute advisory committee on the Restatement of the Law (Third) of Torts: General Principles.

[62]     20. Mark McClellan, M.D., Ph.D.. Dr. McClellan holds a Ph.D. in Economics from the Massachusetts Institute of Technology, an M.D. from the Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, and an M.A. from the Kennedy School of Government at Harvard University. Dr. McClellan is an Assistant Professor of Economics and an Assistant Professor of Medicine at Stanford University, and recently served as Deputy Assistant Secretary for Economic Policy at the Department of the Treasury.

[63]     21. Elizabeth Krupnick. Ms. Krupnick is an expert in communications and President of the Farago & Partners advertising agency. Ms. Krupnick's previous positions in the communications industry include (1) Senior Vice President of Corporate Communications and Advertising at New York Life Insurance Company, (2) Chief Communications Officer and Vice President of The Prudential Insurance Company of America and (3) Senior Vice President of Corporate Affairs for Aetna Life and Casualty.

[64]     Less than thirty class member objectors filed objections to the Settlement Agreement. No public interest group filed any objection to the Settlement. No academic filed any objection to the Settlement. Several Objectors cross examined witnesses at the Fairness Hearing. In addition, some objectors entered various documents and articles into the Fairness Hearing Record.

[65]     D. The Medical Circumstances of the Class

[66]     The record before the court includes a substantial amount of medical testimony and evidence, including approximately ninety clinical and epidemiological studies, which is the foundation for the various monitoring and compensation provisions of the Settlement. By contrast, no expert for any party or any objector testified that any aspect of the Settlement was contrary to the scientific studies or was not a reasonable response to the medical issues raised in the lawsuits that the Settlement will resolve.

[67]     1. The Risk of Valvular Heart Disease

[68]     a. The Heart

[69]     The principal risk created by use of fenfluramine and dexfenfluramine is the risk of valvular heart disease ("VHD"). The human heart has four chambers. The upper chamber on the right side of the heart (the right atrium) functions to receive deoxygenated blood from the body. The lower chamber of the right side of the heart (the right ventricle) pumps the deoxygenated blood through the pulmonary arteries into the lungs where carbon dioxide is removed from the blood and replaced with oxygen. The upper chamber on the left side of the heart (left atrium) receives and collects oxygenated blood which has been pumped from the lungs to the heart through the pulmonary veins. The lower chamber on the left side of the heart (the left ventricle) pumps oxygenated blood from the heart through the aorta and into the arterial system. (Ex. P-95 ¶4; Tr. 5/2/00 at 216; Ex. P-63.)

[70]     Just as the heart has four chambers, it also has four valves. The valve structures function to assure that blood moves through the heart in a forward direction and that effective blood flow is maintained. The valve located between the right atrium and the right ventricle is the tricuspid valve. The valve between the right ventricle and the pulmonary artery is the pulmonic valve. The valve located between the left atrium and the left ventricle is the mitral valve. The valve located between the left ventricle and the aorta is the aortic valve. (Ex. P-95 ¶¶ 5 & 6.)

[71]     b. VHD in General

[72]     VHD is a group of different conditions which cause a disruption in the normal structure and/or function of the heart valves. When a patient suffers from VHD, blood that is supposed to move in a forward direction through the heart leaks backward or "regurgitates" through the diseased valve. (Ex. P-95 ¶ 8.) The existence of VHD and the extent of regurgitation associated with it can be diagnosed with echocardiography--a non-invasive study in which ultrasound waves are used to image cardiac structure and blood flow in the heart. (Ex. P-95 ¶ 9.)

[73]     Apart from VHD related to the use of diet drugs (which is described below), several other conditions are the principal causes of valvular regurgitation in the left side of the heart. (Ex. P-95 ¶ 10.) Each of these other conditions may be diagnosed with an echocardiogram in accordance with accepted, objective criteria. (Ex. P-95 ¶ 10.)

[74]     The prevalence of valvular regurgitation in the general population also varies with the age of the population--with more regurgitation present in older individuals as a result of the normal aging process, as well as their exposure over time to these various diseases or agents that are known to cause such regurgitation. (Ex. P-95 ¶ 16; AHP Ex. 613 ¶ 9; AHP Ex. 610 ¶ 13.) Because there is such a "background" or "control" rate of valvular regurgitation among the general population who never took diet drugs--and because that rate varies with the age of the patients and various other conditions--it is essential that any demonstration of causation with respect to diet drugs and such regurgitation be predicated on controlled studies which, on a blinded basis, compare the prevalence of such regurgitation among those who took the drugs and a similarly-situated population of others who did not. (AHP Ex. 611 ¶¶ 6-10 & 14-16; AHP Ex. 613 ¶ 18; AHP Ex. 610 ¶¶ 7-9.)

[75]     The levels of valvular regurgitation caused by the varying conditions underlying VHD vary in severity. The degree of valvular regurgitation is measured by an echocardiogram in accordance with standardized techniques and criteria. (Ex. P-95 ¶ 11.) Using these techniques of measurement, the degrees of valvular regurgitation are characterized as trace, mild, moderate or severe. (Ex. P-95 ¶ 12.) Such valvular regurgitation occurs to varying degrees in the majority of entirely healthy individuals. As all of the cardiology experts testified, today's echocardiography technology is so sensitive that it can detect even trivial amounts of regurgitation that require no medical treatment and are not a precursor of any disease. (Ex. P-95 ¶ 12; AHP Ex. 613 ¶ 6; AHP Ex. 610 ¶ 11.)

[76]     Mild or greater aortic regurgitation ("AR") and moderate or greater mitral regurgitation ("MR") is frequently referred to as "FDA positive regurgitation" based on the FDA's observation that "[m]inimal degrees of regurgitation (i.e., trace mild mitral regurgitation or trace aortic regurgitation) are relatively common in the general population and are not generally considered abnormal." (Ex. P-95 ¶ 13; Ex. P-182 at 2 & 6 of 13.) All of the experts who testified on this issue agreed that the FDA case definition--which has come to be known as "FDA Positive"--is the appropriate way to define medically relevant valvular regurgitation. Specifically, all the experts testified that the lesser degrees of regurgitation--including mild mitral regurgitation--are common in the general population and have no medical significance. (Ex. P-95 ¶¶ 13, 18; AHP Ex. 613 ¶¶ 6 & 10.)

[77]     Although the progression in severity of valvular regurgitation resulting from conditions other than diet drugs has not been subject to rigorous clinical investigation, it is generally accepted that VHD from such other causes is potentially progressive in nature; that is, once significant valvular regurgitation exists, it tends to beget more severe regurgitation in a significant subset of patients. (Ex. P-95 at ¶ 14.) Clinical experience tends to suggest that the risk of progression of valvular regurgitation is related to the severity of regurgitation in the first instance, with mild forms of regurgitation tending not to progress, and moderate to severe levels of regurgitation tending to be progressive. (Ex. P-95 ¶ 15.) Trace AR, trace MR and mild MR are relatively common conditions, while more severe forms of regurgitation tend to be less common in the general population. See, e.g., Ex. P-95 ¶ 16 (discussing results of Framingham Study).

[78]     The existence and degree of symptoms caused by VHD and the medical care required to manage such disease vary significantly depending upon the degree of valvular regurgitation that the patient presents. Trace AR, trace MR, and mild MR are completely asymptomatic conditions that do not impose any limitations on a patient's ability to function normally. Without some additional factor, such as impaired mobility of the valve "leaflets," patients with trace AR, trace MR and mild MR do not require medical management or treatment. (Ex. P-95 ¶¶ 17 & 18.)

[79]     Mild AR is an asymptomatic condition that does not impose any limitation on an individual's ability to function normally. However, mild AR poses two distinct health risks. First, the abnormal aortic valve is susceptible to bacteria introduced into the blood stream through invasive procedures, such as surgery or normal dental hygiene. This, in turn, creates an increased risk of the patient suffering an infection of the heart valve and surrounding heart muscle known as "bacterial endocarditis." Bacterial endocarditis is an extremely serious and often fatal condition. Patients suffering from bacterial endocarditis can develop severe regurgitation or peripheral emboli which, in turn, can lead to stroke, loss of an extremity or major organ failure. Second, mild AR can progress to more severe levels of valvular regurgitation that can impair the functioning of the heart. (Ex. P-95 ¶ 19; Tr. 5/3/00 at 102-103.)

[80]     Given these risks, the accepted regimen of medical management for patients with mild AR is the prescription of antibiotic prophylaxis in connection with invasive procedures, such as surgery or normal dental hygiene, and periodic evaluation by a cardiologist to determine if the degree of valvular regurgitation in the patient is progressing. (Ex. P-95 ¶ 20.) Typically, the regimen for following such asymptomatic patients is a yearly examination by a cardiologist and serial echocardiographic testing. Since the risk of progression of valvular regurgitation in diet drug-induced VHD is unknown, an echocardiogram should be performed one year after the diagnosis of valvular regurgitation is made. If the aortic regurgitation remains mild, then follow-up echocardiograms should be performed every two to three years to screen for progressive valvular regurgitation. If the valvular regurgitation is found to be more severe on follow-up echocardiographic studies, then the echocardiogram should be performed yearly. (Ex. P-95 ¶ 21.) Mild AR is difficult to appreciate by merely listening for abnormal heart sounds with a stethoscope (auscultation), particularly in obese individuals. Because of this, and because of the risks of endocarditis and progression of asymptomatic disease described above, many physicians believe that patients who are at risk for developing AR should receive screening echocardiograms. (Tr. 5/3/00 at 98-99; Ex. P-95 ¶ 41.)

[81]     At the other end of the spectrum of VHD, severe AR and severe MR are conditions in which the percentage of blood ejected from the heart (the "ejection fraction") can fall significantly below normal. With chronic severe aortic and mitral regurgitation, patients are often asymptomatic at first and become symptomatic when the heart function begins to fail. (Ex. P-95 ¶ 22.) When such patients are symptomatic, their symptoms will include shortness of breath, fatigue and/or diminished exercise capacity. (Ex. P-95 ¶ 23.)

[82]     Severe valvular regurgitation leads to a volume overload of the heart. The size of the left atrium and/or left ventricle tends to increase in response to the volume overload created by severe regurgitation. This phenomenon is described as left ventricular and/or left atrial "dilatation" ("LV/LA"). In addition, the thickness of the walls of the atrium and/or ventricle also tends to increase in response to the volume overload created by severe regurgitation. This process is known as left ventricular hypertrophy and/or left atrial hypertrophy. Over time, heart function will deteriorate, and as the left ventricular ejection fraction decreases, the pressure within the left ventricle increases. This, in turn, will lead to an increase in the pulmonary venous pressures and an increase in the pulmonary artery pressure. This secondary pulmonary hypertension (PH) is a marker of significant cardiac dysfunction and may not return to normal even after valve surgery. In addition, the hypertrophy and dilatation may also be permanent conditions that may not be corrected medically or surgically following valve repair or replacement. (Ex. P-95 ¶ 24.)

[83]     When dilatation and/or hypertrophy progress to a sufficient level of abnormality, the patient is exposed to the following risks, among others:

[84]     . The patient is at risk of developing chronic atrial fibrillation in the case of severe MR, that can lead to a stroke or peripheral embolus;

[85]     . The patient is at risk of developing ventricular fibrillation or ventricular tachycardia, dangerous arrhythmias, that can precipitate the patient's sudden death;

[86]     . The patient has a high risk of developing congestive heart failure, an often fatal condition; and

[87]     . The patient is at risk of developing permanent pulmonary hypertension, that can lead to persistent symptoms of shortness of breath, fatigue, congestive heart failure and death. (Ex. P-95 ¶ 26.)

[88]     Drug therapies can be used in the treatment of severe AR and severe MR, particularly before the patient develops symptoms, hypertrophy, dilatation and/or pulmonary hypertension. These include drugs that increase the strength or the contractility of the heart and drugs that decrease the afterload of the heart to allow the heart to beat more easily. (Ex. P-95 ¶ 27.) However, where a patient with severe MR or severe AR exhibits significant symptoms or begins to exhibit hypertrophy, dilatation and/or pulmonary hypertension (PH), surgery is usually the treatment of choice. Surgery involves the operative repair of the diseased valve, if possible, or the replacement of the diseased valve with either a mechanical valve or a porcine valve. (Ex. P-95 ¶ 28.)

[89]     The average cost of valvular repair or replacement surgery, including both physician and hospital fees, ranges between $30,000-$50,000. (Ex. P-94 at 7-8 of 41.) Valvular repair/replacement surgery in properly selected patients is a safe procedure. The morbidity/mortality associated with valvular repair/replacement surgery during the intra-operative and post-operative period in low risk patients is between 2 and 4 percent, with a long-term morbidity/mortality for such patients averaging about 3 percent per year. (Ex. P-95 ¶ 29.) Patients who undergo valve repair or replacement surgery are normally able to resume their activities of daily living without significant restriction or disability. (Ex. P-95 ¶ 30.)

[90]     However, valvular repair or replacement surgery is not without risk. Patients who receive metallic prosthetic valves must take blood thinning agents for the rest of their lives. Patients who receive tissue valves do not require blood thinners. However, tissue valves are less durable than metallic valves, and over one-third of patients with tissue valves will have valve failure within 11 years of surgery. (Ex. P-95 ¶ 31.) Valve repair/replacement surgery is accompanied by the risk of stroke, peripheral embolus with severe impairment to the kidneys, abdominal organs, or extremities, renal failure, quadriplegia or paraplegia resulting from cervical spine injury and post-operative infection. (Ex. P-95 ¶ 31.) Therefore, the decision to perform valve repair or replacement surgery involves striking a balance between the risks of surgery and the risks of severe regurgitation. (Ex. P-95 ¶ 32.)

[91]     As Dr. Brennan, a public health expert and board-certified internist, testified--and as is well-accepted in the medical literature--the use of echocardiograms to screen and monitor patients who are at some increased risk of developing valvular regurgitation should further reduce the morbidity and mortality associated with possible progression and complications of the disease (which takes years to injure a patient's heart after it can be detected on an echocardiogram) as compared to patients who are not so screened and monitored. Specifically, a higher-risk population that is screened and monitored in this fashion can be treated--either through medication, valve repair or replacement--at the optimal time to reduce the likelihood that they will suffer permanent heart damage or other complications of unchecked valve disease. No expert testified to the contrary. (Tr. 5/3/00 at 101-104, 114-116.)

[92]     Given the above, the regimen to be followed in the management of patients suffering from severe AR and severe MR consists of:

[93]     1. prescribing antibiotic prophylaxis in connection with any invasive procedures, such as surgery or dental hygiene;

[94]     2. frequent examination and evaluation of the patient by a cardiologist, including frequent use of echocardiograms, to assess the degree of regurgitation, the presence and extent of LV/LA dilatation, the presence and extent of LV/LA hypertrophy, the patient's ejection fraction, the patient's pulmonary artery pressure, the patient's symptom status and other cardiovascular parameters;

[95]     3. treatment with medication; and

[96]     4. surgery, where indicated. (Ex. P-95 at ¶ 33.)

[97]     Finally, moderate MR and moderate AR are asymptomatic conditions that do not impair an individual's ability to function normally. Typically, these conditions pose the same risk and require the same regimen of medical management as that which is appropriate for the management of mild AR. However, when moderate MR and/or moderate AR approach the level of severe regurgitation, the patient can begin to develop PH, LV/LA dilatation, and LV/LA hypertrophy. When such conditions develop, it is appropriate to treat the patient in the same manner as one would treat a patient who had severe regurgitation with such findings. (Ex. P-95 ¶ 34.) c. VHD and Diet Drugs

[98]     The relationship between the ingestion of the fenfluramine derivatives and VHD has been subject to extensive scientific investigation. Since the withdrawal of Pondimin and Redux from the market in September 1997, a number of investigators have conducted controlled studies that have compared the prevalence of valvular regurgitation among patients who previously took fenfluramine, dexfenfluramine or the Fen/Phen combination to similarly situated subjects (i.e., matched controls) who had not taken diet drugs. There are 14 principal studies and a number of other investigations that studied a total of more than 12,000 patients who took fenfluramine and/or dexfenfluramine for varying lengths of time. (Exs. P-113, P-127, P-170, P-172, P-173, P-122, P-115, P-153, P-228, P-111, P-118, P-119, P-126, P-138, P-148 & P-149.) As stated in a February 1999 Review article that summarized a number of these studies, "Fenfluramine and more recently its d-isomer Dexfenfluramine have been the most extensively studied anorexic drugs for the past 30 years." (Dunn LT 84 at 123.) Although these studies vary in their design, each is a valid scientific study supported by the undisputed expert testimony as reliable and authoritative.

[99]     As a result of the unprecedented amount of study that diet drug-related valvulopathy has received, it is possible to reach reliable conclusions regarding the nature of the disease process, the effect of duration of use, latency, progression, incidence and prevalence. It appears clear that the fenfluramine derivatives, Pondimin and Redux, cause valvular heart disease by producing plaques that become "stuck-on" to the valve structures causing regurgitant lesions. (Ex. P-113.) Equally clear is that there is a duration-response relationship between exposure to the drugs and the development of regurgitant lesions. An enormous body of epidemiologic data from the authoritative, reliable studies described above establishes with a high degree of confidence that the population of patients who took fenfluramine and/or dexfenfluramine for less than three months does not have a significant increased risk of FDA Positive levels of valvular regurgitation. (Tr. 5/3/00 at 93-96; Ex. P-90 ¶ 5; Tr. 5/8/00 at 24; Ex. P-122; AHP Ex. 587A; Ex. P-115; Ex. P-228; Ex. P-170.)

[100]    Moreover, although short-term therapy with Pondimin or Redux was reported to produce an increased risk when both FDA Positive and non-FDA levels of regurgitation were considered, there was no longer a significant difference between exposed and control subjects when the same population was re-evaluated 3 to 5 months after discontinuation of the use of the drugs and again at one year after discontinuation. (Exs. P-172 & P-173.) In contrast, there is epidemiologic evidence that the use of fenfluramine or dexfenfluramine for durations of three to six months or longer produces a significant increased risk of FDA Positive levels of regurgitation and that this risk increases in proportion to the duration of therapy. (Ex. P-90 ¶ 5; Tr. 5/5/00 at 24; Tr. 5/3/00 at 96.)

[101]    With respect to the levels of regurgitation which the FDA has defined as medically relevant ("FDA Positive"), the studies are consistent in finding that the only increased risk of such regurgitation among patients who previously took fenfluramine or dexfenfluramine is a risk of mild aortic regurgitation, and that such increased risk does not occur until patients took the drugs for a "threshold" duration of three to six months or more. (Tr. 5/3/00 at 94-95; AHP Ex. 609 ¶ 8; Tr. 5/8/00 at 78-79; AHP Ex. 611 ¶ 17; AHP Ex. 610 ¶ 10.) All of the other clinical studies are consistent with this durational finding with respect to the association between FDA Positive aortic regurgitation and the use of the drugs. Specifically, in the Ryan-Jollis, Weissman I, Weissman II, Weissman III, Gardin I, Gardin II and Davidoff Studies, there was no statistically significant increase in the prevalence of FDA Positive aortic regurgitation among the patients who had taken fenfluramine, dexfenfluramine, or the fen-phen combination for three months or less. (AHP Ex. 174A at Table 2; AHP Ex. 175 at 10; P-170 at Tables 1 and 2; P-172 at Tables 1 and 2; AHP Ex. 185A at Tables 1-4; P-122 at 1706; AHP Ex. 587A; AHP Ex. 121 at 11, 20 & 28; Tr. 5/3/00 at 94-95; AHP Ex. 609 ¶ 8; Tr. 5/8/00 at 78-79; AHP Ex. 611 ¶ 17; AHP Ex. 610 ¶ 10.)

[102]    With respect to the relative prevalence of mitral regurgitation, the controlled clinical studies do not demonstrate a statistically significant increased risk of FDA Positive (moderate or greater) mitral regurgitation regardless of duration of use. For example, the Ryan-Jollis Study found that--in comparison to a background rate of 2 percent of FDA Positive mitral regurgitation among the untreated control subjects--none of the patients treated with the fen-phen combination for 90 days or less, 2 percent of the patients treated for 90 to 180 days, 3 percent of the patients treated 181 to 360 days, 3 percent of the patients treated 361 to 720 days, and 2 percent of the patients treated for 720 days or more had such regurgitation. None of these slight differences was statistically significant for any of the durational subgroups, nor was the rate of FDA Positive mitral regurgitation among all of the treated patients taken as a whole (2.5 percent) significantly different from the control rate of 2 percent. (AHP Ex. 175 at 12.)

[103]    All of the other controlled clinical studies similarly found that there was no statistically significant increased risk of FDA Positive (moderate or greater) mitral regurgitation among patients treated with fenfluramine, dexfenfluramine, or the fen-phen combination, regardless of duration of use. (Exs. P-153 at 2163; P-130 at Table 2; P-170 at Table 2; P-172 at Table 2; AHP Ex. 185A; P-122 at 1707; AHP Ex. 587A; AHP Ex. 121 at 13; AHP Ex. 609 ¶ 8; AHP Ex. 611 ¶ 18; AHP Ex. 610 ¶ 10.) None of the clinical studies have reported an increased risk of either tricuspid or pulmonic regurgitation among patients treated with fenfluramine or dexfenfluramine regardless of duration of use. (Exs. P-170, P-115, P-111 and P-122.)

[104]    All of the expert witnesses who testified in this case and expressed an opinion with respect to the increased risk of medically significant valvular regurgitation likewise agreed that increased risk among former fenfluramine or dexfenfluramine patients is limited to the aortic valve and begins at a "threshold" level of at least three months or more. No expert testified to the contrary. (Tr. 5/3/00 at 93-95; AHP Ex. 609 ¶ 8; AHP Ex. 613 ¶¶ 43-58; AHP Ex. 611 ¶¶ 17-32; AHP Ex. 610 ¶ 10.)

[105]    The state of scientific knowledge concerning diet drug induced valvular heart disease was recently summarized by a prominent pharmaco-epidemiologist, Hershel Jick, in a recent editorial in the Journal of the American Medical Association as follows:

[106]    [m]illions of patients were prescribed Fenfluramines prior to 1997. For the substantial majority who took the drug for less than three months, the risk of heart valve disorders appears to be minimal. In those who took the drugs longer than three months, many will have developed echocardiographic evidence of cardiac valve disorders, particularly mild AR. In the majority of instances, these abnormalities most likely are benign and are unlikely to lead to clinical disease. However, a small proportion of patients have substantially increased risk for clinically important valvulopathy and cardiovascular consequences as a result of taking anorexigens. However, because Fenfluramines have been unavailable since 1997, judgments about the overall consequences of Fenfluramine use are likely to be limited to the results of those studies already completed. Ex. P-128 at 2-3.

[107]    In sum, the medical situation of individuals who used AHP's products, Pondimin and Redux, is as follows. First, because the population of individuals who took diet drugs for more than three or four months is at an increased risk of asymptomatic valvular heart disease, it is appropriate for them to have a screening echocardiogram to determine if they have developed VHD as a consequence of exposure to Pondimin and Redux. Second, to the extent that diet drug recipients manifest FDA Positive levels of regurgitation, they require antibiotic prophylaxis and ongoing medical surveillance to determine if there is progression in their condition such that further medical treatment or intervention is appropriate. (Tr. 5/3/00 at 102-103.) Finally, if diet drug recipients have or develop serious levels of regurgitation (defined as either severe regurgitation or moderate regurgitation with dilatation, hypertrophy, reduced ejection fraction, or pulmonary hypertension) then such individuals suffer disabling conditions for which substantial compensation is warranted.

[108]    2. The Risk of Primary Pulmonary Hypertension ("PPH")

[109]    PPH is a disease that affects pulmonary circulation. PPH is characterized by scarring and fibrosis of the pulmonary arteries which carry deoxygenated blood from the right side of the heart to the lungs. This scarring prevents the blood cells from effectively absorbing oxygen as they pass the alveoli in the lungs. Moreover, the scarring within the pulmonary arteries obstructs the flow of blood within the vessels, causing the blood pressure in the pulmonary arteries pressure to rise. The right ventricle of the heart attempts to overcome the increasing resistance to the flow of blood through the pulmonary arteries by growing larger and more muscular. Ultimately, this dilatation and hypertrophy of the right ventricle will cause the heart to fail and result in the patient's death. (Tr. 5/2/00 at 223-27 & 231-32.)

[110]    PPH is a relentlessly progressive disease that leads to death in virtually all circumstances. The only approved treatment for the disease involves the administration of a drug known as Prostacyclin ("Flolan"), which must be administered continuously through an intravenous pump. Flolan is not a cure for the disease. If it is used successfully, it can reduce the patient's symptoms and delay death for a few years. Administration of the drug is accompanied by a high incidence of serious complications. The drug can cause death if administered to patients who do not suffer from PPH, and is thus contraindicated for use in such patients. (Tr. 5/2/00 at 237-245.)

[111]    The proper diagnosis of primary pulmonary hypertension is extremely important for two reasons. First, the diagnosis is accompanied by enormous psychological trauma to the patient because it is a virtual death sentence. Second, proper diagnosis is important because the treatment administered as a result of the diagnosis is extraordinarily dangerous in patients who do not, in fact, suffer from the disease. (Tr. 5/2/00 at 236-38, 242-43.)

[112]    The community of physicians with expertise in diagnosing and treating PPH have repeatedly reached a consensus concerning the appropriate criteria for diagnosing and defining the disease. This consensus was expressed at the World Health Organization meeting in 1973, in a statement of the American College of Chest Physicians in 1993 and in the Executive Summary of the World Symposium on Primary Pulmonary Hypertension in 1998. In addition, this "consensus definition" of PPH was expressed in every major epidemiologic study concerning the disease that has ever been done. The consensus for defining and diagnosing PPH has three elements. The first of the three criteria necessary to make a diagnosis of primary pulmonary hypertension is a mean pulmonary artery pressure ò 25 mm Hg at rest or ò 30 mm Hg with exercise as measured at cardiac catheterization. *fn2 (Tr. 5/2/00 at 230-31, 254-55, 259-62, 265 & 268-69; Tr. 5/3/00 at 13.)

[113]    There are many conditions aside from PPH that can cause an elevation in pulmonary artery pressure. These include systemic hypertension (i.e., "high blood pressure") and a variety of diseases which affect the left side of the heart including cardiomyopathy, mitral stenosis, pulmonary vein obstruction, a stiff left ventricle, and like conditions. Because PPH is a disease that originates in the pulmonary arterial system, patients with the disease will have normal pressures in the left side of their heart even though they have abnormal pressures in the right side of their heart. In contrast, patients who have conditions other than PPH that result in an elevated pulmonary artery pressure will have an elevation in the "pulmonary capillary wedge pressure" which accurately reflects the pressure in the left atrium. The only way to measure pulmonary capillary wedge pressure is through a cardiac catheterization. Accordingly, the second criterion necessary for the diagnosis and treatment of PPH is the presence of a "normal" pulmonary capillary wedge pressure of ó 15 mm Hg. (Tr. 5/2/00 at 230-31, 258-62, 266, 268-69 & 279-80; Tr. 5/3/00 at 13, 53-54.)

[114]    Finally, PPH is a diagnosis of exclusion. Therefore, in order to reach the diagnosis, all "secondary" causes of pulmonary hypertension must be excluded. These include diseases known to be associated with pulmonary hypertension such as collagen vascular disease, congenital systemic to pulmonary shunts, portal hypertension, toxin-induced lung disease, significant obstructive sleep apnea, interstitial fibrosis (such as silicosis, asbestosis, or granulomatous disease), HIV infection and others. (Tr. 5/2/00 at 17, 19-20.)

[115]    The normal incidence of PPH in the population is 1 to 2 new cases per million people per year. Two well done epidemiologic studies establish that the use of fenfluramine and dexfenfluramine cause PPH. (Exs. P-209 & P-175.) In 1996, Dr. Abenhaim and his colleagues published the results of the International Primary Pulmonary Hypertension Study. This study demonstrated that the risk of developing PPH in individuals who used fenfluramine longer than three months increased twenty-three fold. (Ex. P-209.) In March of 2000, the journal CHEST published the results of an epidemiologic study entitled the Surveillance of North American Pulmonary Hypertension. This study confirmed the association between the use of fenfluramine derivatives and PPH. (Ex. P-175.)

[116]    E. The Legal Circumstances of the Class

[117]    Diet drug recipients have faced and will continue to face significant legal obstacles in obtaining appropriate relief. First, the statutes of limitation in various states pose significant obstacles to recovery. Most jurisdictions have a "discovery rule," which holds that an individual must commence suit within a specified period of time after he or she knows, or in the exercise of reasonable diligence, should have known that they have suffered an injury and that it was caused by the defendant. See e.g., Pearce v. Salvation Army, 674 A.2d 1123, 1125 (Pa. Super Ct. 1996); Cochran v. GAF Corp., 666 A.2d 245 (Pa. 1995); HECI Exploration Co. v. Neel, 982 S.W.2d 881, 886 (Tex. 1998). Pondimin and Redux were withdrawn from the market in September 1997 accompanied by an unprecedented amount of publicity which effectively warned diet drug users that they may have developed valvular lesions which could be detected through non-invasive echocardiograms. Also, these lesions are not latent. If they are going to occur, they are going to occur during drug use (or shortly thereafter) and be demonstrable on echocardiogram. Therefore, AHP has an argument that diet drug users, acting with reasonable diligence, should have learned that they had heart valve damage as a result of using Pondimin and Redux beginning with the withdrawal of the drugs from the market in September 1997. Since most states have statutes of limitation of two years or less, AHP could argue that the statute of limitations has run on claims of valvular heart damage by most diet drug recipients. Even though there are approximately 18,000 individuals who have commenced actions against AHP, at present this means that a substantial number of viable claims by diet drug recipients could be time-barred. (Tr. 5/2/00 at 34-35.)

[118]    Moreover, because of vagaries in the law governing recovery for potentially progressive injuries, the damage claims of individuals who are not presently suffering from serious diet drug-induced VHD are potentially subject to the following types of resolution by the courts:

[119]    1. many courts may hold that such plaintiffs are not entitled to any recovery of damages at the present time because they do not have a "symptomatic" injury, but that a cause of action will accrue in the future without a statute of limitations time bar if their disease progresses to a symptomatic level;

[120]    2. many courts may hold that plaintiffs can recover compensatory damages for asymptomatic valve disease today and that a separate cause of action may accrue in the future, without a statute of limitations time bar, in the event that their disease progresses to a more serious level; and

[121]    3. many jurisdictions may hold that claimants can recover compensatory damages for their asymptomatic valvular heart disease at the present time, but will never recover for the risk of future progression because that risk is too speculative, does not meet "more likely than not" standards, and/or because valvular heart disease is not subject to a "two disease" rule that recognizes the accrual of two separate causes of action where there are more serious manifestations of an underlying disease process. (Tr. 5/2/00 at 34-35.)

[122]    Thus, it would be beneficial for diet drug recipients to obtain appropriate legal protections such that they have a viable claim for relief when, as, and if, they discover they have either FDA Positive levels of regurgitation or that they have serious VHD.

[123]    F. The Settlement

[124]    1. The Class

[125]    On October 12, 1999, a complaint entitled Brown v. American Home Products Corporation was filed in this action. (Class Action Compl. Ex. P-1; Am. Class Action Compl. Ex. P-2; Second Am. Class Action Compl. Ex. P-65.) The Brown Complaint was filed as a vehicle for combining the claims of class members asserted in pending federal and state diet drug litigation throughout the country into a single complaint to facilitate class action treatment of those claims for settlement purposes. (Tr. 5/2/00 at 56-57.) The Settlement Agreement was reached with respect to a class consisting of all persons in the United States who ingested Pondimin and Redux and their associated consortium claimants. (Ex. P-3 at 19 of 148.) The class includes five discrete subclasses:

[126]    Subclass 1(a): those class members who took Pondimin or Redux for 60 days or less and who have not been diagnosed as having FDA Positive levels of valvular regurgitation by September 30, 1999;

[127]    Subclass 1(b): those class members who ingested Pondimin or Redux for 61 days or more and who, likewise, have not been diagnosed as having FDA Positive levels of valvular regurgitation as of September 30, 1999;

[128]    Subclass 2(a): those class members who ingested Pondimin or Redux for 60 days or less and who have been diagnosed as having FDA Positive levels of valvular regurgitation as of September 30, 1999;

[129]    Subclass 2(b): those class members who ingested Pondimin or Redux for 61 days or more and who have been diagnosed as having FDA Positive levels of valvular regurgitation by September 30, 1999; and

[130]    Subclass 3: those class members who ingested Pondimin or Redux and who are not FDA Positive but who have been diagnosed as having Mild Mitral Regurgitation. (Ex. P-3 at 19-21 of 148.)

[131]    2. The Benefits of the Settlement

[132]    a. Medical Monitoring, Medical Screening and Matrix Compensation Benefits

[133]    The Settlement Agreement provides that all persons who took diet drugs for 61 days or more who were not diagnosed as "FDA Positive" by September 30, 1999 (i.e., members of Subclass 1(b) as defined above) are entitled to receive a state-of-the-art transthoracic echocardiogram and a consultation with a cardiologist concerning the results of that echocardiogram. (Ex. P-3 at 34 of 148.) The Settlement Agreement makes certain provisions for members of Subclass 1(a) (those who took diet drugs for 60 days or less) to obtain monitoring relief in certain circumstances. In particular, members of Subclass 1(a) are entitled to recover the net out-of-pocket costs which they incur for echocardiograms conducted during the screening period if they are diagnosed as having FDA Positive valvular regurgitation. (Ex. P-3 at 35-36 of 148.) In addition, the Settlement Trustees may, at their discretion and in appropriate cases for compassionate and humanitarian reasons, provide a transthoracic echocardiogram and an associated interpretive physician visit for members of Subclass 1(a). *fn3 (Ex. P-3 at 36 of 148.) In addition, the Settlement Agreement provides that members of Class 1(a) and 1(b) can obtain echocardiograms upon trial court approval of the settlement in the case of financial hardship. *fn4 (Ex. P-3 at 37 of 148; Ex. P-32 at 2 of 13.)

[134]    The period of time provided during which echocardiograms described in the foregoing findings are to be completed under the terms of the Settlement Agreement (the "Screening Period") is 12 months from the date on which the settlement receives "Final Judicial Approval." As defined in the Settlement Agreement, Final Judicial Approval refers to the approval of the Settlement Agreement as a whole by the district court and such approval becoming final by the exhaustion of all appeals, if any, without substantial modification of the order or orders granting such approval. The court may extend the Screening Period for an additional six months for cause shown. (Ex. P-3 at 10 & 12 of 148.) Class members who wish to receive the medical monitoring benefits described above must register to receive such benefits by Date 1, which is 210 days after the date of Final Judicial Approval. (Ex. P-3 at 9 & 34-36 of 148.)

[135]    The medical monitoring benefits are to be furnished free of charge by a Trust Fund established under the Settlement Agreement as described in greater detail below. (Ex. P-3 at 34-36 of 148.) It is expected that the Trust will contract with a network of approximately 10,000 board certified or board eligible cardiologists located throughout the country who are qualified to perform and interpret echocardiograms and to consult with patients concerning the results of those echocardiograms. (Tr. 5/2/00 at 69; Tr. 5/9/00 at 25-31.) This network will be sufficiently extensive to provide class members with the opportunity to choose among several conveniently located cardiologists to perform the monitoring services provided by the Settlement Agreement regardless of whether class members reside in a rural or urban setting. (Tr. 5/2/00 at 69; Tr. 5/9/00 at 25-31.) It is expected that, on average, the Trust's cost to provide an echocardiogram and interpretive physician visit pursuant to the Settlement Agreement will average approximately $800 per class member. (Tr. 5/2/00 at 69; Tr. 5/9/00 at 31.)

[136]    Each class member who is diagnosed as having Mild Mitral Regurgitation by the end of the screening period and who registers as such by a date which is 120 days after the end of the Screening Period (defined in the Settlement Agreement as "Date 2") will be entitled to recover compensatory damages pursuant to a settlement "matrix" in the event that they develop serious levels of mitral regurgitation by the year 2015, or, alternatively, each such person may exercise a "back-end opt-out." (Ex. P-3 at 38-56 & 61-63 of 148.) With respect to any class member who properly and timely exercises a right of back-end opt-out, AHP may not raise a defense based on a statute of limitations or repose or a defense based on improper splitting of a cause of action. By the same token, any class member exercising a back-end opt-out may not recover punitive, exemplary or multiple damages against AHP, and may not use any prior verdicts or judgments against AHP under the doctrines of collateral estoppel, res judicata, or other doctrine of issue or claim preclusion. (Ex. P-3 at 61-63 of 148.)

[137]    If a class member learns that he or she has FDA Positive levels of regurgitation after September 30, 1999 but before the end of the Screening Period, that individual has the right to opt out of the settlement and to pursue a claim for compensatory damages in the tort system without meeting the bar of the statute of limitations or a defense of splitting of causes of action and without relying on any prior verdicts or judgment against AHP under the doctrines of collateral estoppel, res judicata, or other doctrine of issue or claim preclusion. This "intermediate opt-out" right is in addition to the initial opt-out right of all class members. (Ex. P-3 at 57-60 of 148.)

[138]    Those individuals who have FDA Positive levels of regurgitation but do not exercise an initial or intermediate opt-out right have the right to receive medical services from the Settlement Trust to the extent appropriate to monitor their VHD. Such services may include periodic medically appropriate echocardiograms, cardiology consultations, chest x-rays, laboratory studies, electrocardiograms and other services necessary and appropriate to determine the cardiac status of individuals who have FDA Positive levels of valvular regurgitation. (Ex. P-3 at 38 of 148.) Class members may elect to receive cash in lieu of the provision of such services. For class members who took diet drugs 61 or more days and who have FDA Positive levels of regurgitation, the settlement provides that they shall receive $10,000 in medical services or $6,000 in cash. For class members who took AHP's diet drugs for 60 days or less, the agreement provides that they shall receive $5,000 in medical services or $3,000 in cash. *fn5 (Ex. P-3 at 34-36 & 38 of 148.)

[139]    Finally, if class members with FDA Positive levels of regurgitation progress to serious levels of VHD by the year 2015, they will have a right, as such conditions occur, to receive compensation pursuant to the terms of the settlement matrices or to exercise a "back-end opt-out" and pursue their claim for compensatory damages (but not punitive damages) in the tort system without any time bar or other defense arising from a statute of limitations, a statute of repose or the like. (Ex. P-3 at 38-56, 61-63 of 148.) Class members who progress to more serious levels of valvular heart disease have the right to "step up" to higher amounts of compensation as those levels occur pursuant to the settlement matrices. (Ex. P-3 at 38-56 of 148.)

[140]    There are four matrices under the settlement. Matrix A-1 describes the compensation available to diet drug recipients with serious VHD who took diet drugs for 61 days or longer, who are registered as having FDA Positive levels of valvular regurgitation by Date 2 and who do not have any of the alternative causes of VHD that make the B matrices applicable. (Ex. P-3 at 39-55 of 148.) Matrix A-2 describes the compensation available to spouses, parents, children and significant others of diet drug recipients entitled to compensation on Matrix A-1. (Ex. P-3 at 39-55 of 148.)

[141]    Matrix B-1 describes the compensation available to class members with serious VHD who were registered as having only Mild Mitral Regurgitation by the close of the Screening Period, or who took diet drugs for 60 days or less, or who have factors that would make it difficult for them to prove that their VHD was caused by the use of diet drugs. Id. These conditions include most conditions that are objectively identifiable as causes of VHD independent of the use of diet drugs. (Ex. P-3 at 39-55 of 148.) Matrix B-2 describes the compensation available to the spouses, parents, children and significant others of those entitled to compensation on Matrix B-1. (Ex. P-3 at 39-55 of 148.)

[142]    The matrices are composed of cells formed by the intersection of five separate matrix levels of severity and 11 separate age intervals ranging from diet drug recipients who are less than or equal to 24 years old to diet drug recipients who are 70 to 79 years of age. Generally, the amount of compensation provided by the matrices decreases with age both because younger individuals have a longer damage period and because, as discussed above, age increasingly confounds the effects of diet drugs in producing valvular regurgitation. (Tr. 5/2/00 at 76-77.)

[143]    The levels of VHD described on the settlement matrices correspond with the medical consensus regarding the stages of serious VHD. Level I describes those individuals who either have severe regurgitation or have suffered bacterial endocarditis. Level II describes those individuals with moderate to severe regurgitation who have evidence of changes in their cardiac status such as hypertrophy, dilatation, reduced ejection fraction, pulmonary hypertension and the like. Level III describes those individuals who have or need valvular repair or replacement surgery. Level IV describes those individuals who suffer from either complications of valvular surgery or whose disease has progressed to the point that surgery is not an effective remedy. Level V describes those individuals whose VHD is so far advanced that it is terminal. (Ex. P-95 ¶ 48; Ex. P-3 at 40-50 of 148.) Each cell formed by the intersection of an age interval with a severity level describes the amount of compensation to which a claimant meeting those criteria is entitled.

[144]    Class members do not have to demonstrate that their injuries were caused by ingestion of Pondimin and Redux in order to recover Matrix Compensation Benefits. Rather, the Matrices represent an objective system of compensation whereby claimants need only prove that they meet objective criteria to determine which matrix is applicable, which matrix level they qualify for and the age at which that qualification occurred. (Ex. P-3 at 38-56.)

[145]    In addition, the amounts specified by each cell of each matrix will be increased by 2% per year to provide protection against inflation for individuals who qualify for such payments in the future. This two percent increase is sufficient protection against inflation given the historical annual rate of change in the consumer price index. (Tr. 5/2/00 at 78; Ex. P-3 at 55-56 of 148; Ex. P-94 at 3 of 41.) Under the Settlement Agreement, the determination of a matrix benefit is not subject to the exercise of discretion by the Administrators of the Settlement or by any court. Rather, benefits determinations are based on the sworn certification of a board certified physician--primarily a board certified cardiologist or cardiothoracic surgeon--that a class member either has or does not have each of the conditions applicable under the settlement matrices. (Tr. 5/2/00 at 79; Ex. P-3 at 101-02 of 148.) In order to prevent fraud, the settlement requires the Trustees to perform a quarterly audit of five percent of the total claims for Matrix Compensation Benefits in accordance with a plan of audit adopted by those responsible for administration of the settlement. In addition, the settlement permits AHP to submit additional claims for quarterly audit of up to 10% of the matrix claims submitted and 10% of the non-matrix claims submitted. *fn6 (Ex. P-278 ¶ 31.) The audit procedure requires those responsible for administration of the settlement to gather all medical records relevant to the audited claim and forward them to a highly qualified independent board certified cardiologist who is responsible for making a determination as to whether or not there was a reasonable medical basis for the representations made by any physician in support of the claim. (Ex. P-3 at 111-15 of 148.) If the auditing cardiologist makes the determination that there was a reasonable medical basis to support the class member's claim and there is no substantial evidence that fraud was committed in connection with the claim, the claim is to be allowed. Id. If not, those responsible for the administration of the settlement are required to apply to the court for relief. Id. The relief available to the court upon such an application includes an order disallowing the claim, an order directing an additional audit of other claims involving the same attorney and/or physician who was involved in the claim, an order directing such other additional audits as may be appropriate, an order imposing penalties including the payment of costs and attorneys fees and an order making a referral of the matter to the United States Attorney or other appropriate law enforcement officials for criminal prosecution if there is probable cause to believe that the claim was submitted fraudulently. Id.

[146]    b. Prescription Reimbursement Benefits

[147]    The average Redux prescription cost $54.82 per month. The average Pondimin prescription cost $29.22 per month. Class members arguably had a right to recover these prescription costs under the consumer fraud theories advanced in many jurisdictions. Under the Settlement Agreement, class members who took diet drugs for 60 days or less have the right to receive reimbursement of the costs of purchasing Pondimin and/or Redux at the rate of $30 per month for prescriptions of Pondimin and $60 per month for prescriptions of Redux. Eligible class members must register for this benefit by Date 1. (Ex. P-3 at 35 of 148.) Class members who took diet drugs for 61 days or more have the right to receive reimbursement for the cost of their Pondimin and/or Redux prescriptions, subject to a maximum payment of $500 and further subject to the availability of money within Fund A after payment of all other benefits. Eligible class members must register for this benefit by Date 1. (Ex. P-3 at 35 of 148.)

[148]    c. Reimbursement of Echocardiogram Expenses

[149]    Under the consumer protection laws of many states, class members arguably had the right to recover the cost of echocardiograms which they incurred as a consequence of their exposure to Pondimin and Redux. Under the Settlement Agreement, class members have the right to be reimbursed the net out-of-pocket expenses of obtaining echocardiograms outside of the medical monitoring program subject to the availability of money within Fund A after payment of all other benefits except prescription reimbursement benefits for those who took diet drugs 61 days or longer. Eligible class members must register for this benefit by Date 1. (Ex. P-32 ¶ 2.)

[150]    d. Establishment of a Medical Research Fund

[151]    The Settlement Agreement requires the establishment of a $25 million fund to be used to finance medical research and education related to heart disease. Specifically, the settlement requires the creation of a non-profit corporation named the "Cardiovascular Medical Research and Education Fund" to be managed by a Board of Directors consisting of seven persons. Twenty five million dollars in Settlement Funds are to be provided to the corporation. The corporation is required to solicit proposals for grants to physicians, scientists, researchers, healthcare providers and others for purposes of performing medical research or providing medical education concerning heart disease which will be beneficial to the settlement class. The corporation may provide individual grants not to exceed $2 million in response to such proposals upon a finding that the research or educational proposal made by the grant applicant will benefit the members of the class and the grant applicant undertakes, in writing, to submit the results of any research conducted pursuant to any grant proposal for publication by a peer reviewed journal. (Ex. P-3 at 36-37 of 148; Ex. P-7.)

[152]    e. Establishment of a Registry/Database

[153]    In order to obtain benefits under the Settlement Agreement, all class members must submit one of several claim forms which requires: (1) basic personal information including the age and gender of the claiming class member; (2) information about both the use of Pondimin and Redux and the period of time during which it was used; (3) if the claim is based, in whole or in part, on the results of an echocardiogram, a copy of both the report of the echocardiogram and the videotape or computer disk on which the image of the echocardiogram is stored; and (4) if the claimant is making a claim for matrix benefits, relevant information from a board certified cardiologist on the claimant's condition and certain medical records. (Ex. P-3 at 87-91 of 148; Exs. P-12, P-17, P-24 & P-25.) Class members may either furnish the requested information directly or have the Settlement Administrators obtain it through execution of appropriate authorizations. (Ex. P-3 at 87-91 of 148; Exs. P-12, P-17, P-24, & P-25.)

[154]    This information is to be recorded in a computerized database suitable for use with standard medical research software and maintained as a "registry" for purposes of administering the settlement and for purposes of medical education and research. (Ex. P-3 at 91-95 of 148.) After redaction of all patient identifying information, the registry/database is to be made available to persons who: (1) provide written proof of their training, qualifications and experience to conduct medical research; (2) provide a research protocol setting forth the purposes for which they seek access to the registry, the research methodology, source of funding and a description of how the proposed research will benefit the settlement class; (3) undertake, in writing, to use the information they receive from the registry solely for medical, scientific and educational purposes; (4) undertake upon completion of the research to provide the Settlement Administrators, the court, AHP and Class Counsel with a copy of any publication based in whole or in part on the information contained in the registry; and (5) undertake not to testify at any time on behalf of any party in any lawsuit relating to the use of Pondimin and/or Redux. (Ex. P-3 at 91-95 of 148.)

[155]    f. The Public Health Benefits of the Settlement

[156]    The benefits provided by the Settlement Agreement will significantly contribute to the protection and advancement of the public health. Specifically, the provision of screening echocardiograms under the settlement will allow for early diagnosis of individuals with asymptomatic VHD. Such early diagnosis will permit these individuals to receive antibiotic prophylaxis when having dental and surgical procedures, thereby minimizing the risk they would otherwise have of suffering from bacterial endocarditis. Moreover, early diagnosis of asymptomatic VHD together with the medical surveillance benefits offered by the settlement will allow patients to be carefully monitored over time to determine if the level of regurgitation attributable to their valve disease is progressing. This will permit these individuals to obtain medical and surgical treatment of their valve disease before they suffer irreversible injuries to their heart such as dilatation, hypertrophy, reduced ejection fraction and secondary pulmonary hypertension. In addition, the medical research and medical registry provisions of the Settlement Agreement provide a means to conduct extensive research with respect to the diagnosis and treatment of VHD in general and diet drug induced valvulopathy in particular. Collectively, implementation of these provisions will undoubtedly reduce the morbidity and mortality that would otherwise be attributable to diet drug induced valvular heart disease. (Tr. 5/3/00 at 110-12 & 115-16; Ex. P-95 ¶ 41.)

[157]    g. Exit Rights

[158]    The Settlement Agreement provides multiple opportunities for class members to gain information concerning the injuries they have suffered as a result of taking Pondimin and Redux and to opt-out of the settlement in light of the information gained through those opportunities. The Settlement Agreement actually provides for four separate opt-out opportunities. All class members were eligible to exercise an "initial opt-out right" by submitting a notice of their intention to opt-out by March 30, 2000--a date that was 120 days from the date on which the class notice process commenced. (Ex. P-3 at 57 of 148; Pretrial Order Nos. 997 & 998.) Each class member who has timely and properly exercised an initial opt-out right may initiate, continue with, or otherwise prosecute any legal claim against AHP without any limitation, impediment or defense arising from the terms of the Settlement Agreement and subject to all defenses and rights which AHP would otherwise have in the absence of the Settlement Agreement. *fn7 (Ex. P-3 at 57 of 148.)

[159]    All class members who are not members of Subclasses 2(a), 2(b) or 3 and who have been diagnosed as having FDA Positive levels of regurgitation by the end of the Screening Period may exercise an "intermediate opt-out right." (Ex. P-3 at 57-60 of 148.) A class member who timely and properly exercises an intermediate opt-out right may pursue all claims against AHP based on injury to the valve or valves which were diagnosed as having FDA Positive regurgitation except claims for punitive, multiple or exemplary damages, consumer fraud damages and medical monitoring. (Ex. P-3 at 57-60 of 148.)

[160]    Each class member who wishes to exercise a right of intermediate opt-out must do so by submitting a written notice of his or her intent to do so no later than Date 2. (Ex. P-3 at 57-60 of 148.) With respect to each class member who timely and properly exercises the intermediate opt-out right and initiates a lawsuit against the AHP Released Parties within one year from the date on which the intermediate opt-out right is exercised, the AHP Released Parties shall not assert any defense based on any statute of limitations or repose, the doctrine of laches, any other defense predicated on the failure to timely pursue the claim, any defense based on "splitting" a cause of action, any defense based on any release signed pursuant to the Settlement Agreement and/or any other defense based on the existence of the Settlement Agreement. (Ex. P-3 at 57-60 of 148.)

[161]    All class members who are diagnosed as having mild or greater mitral regurgitation or mild or greater aortic regurgitation by the end of the Screening Period, who reach a matrix level condition after September 30, 1999, but before December 31, 2015 and who have registered for settlement benefits by Date 2 are entitled to exercise a "back-end opt-out." (Ex. P-3 at 61-63 of 148.) Each class member who wishes to exercise a right of back-end opt-out must submit a written notice of intent to do so within the latter of 120 days of the date on which the class member first knows (or should have known in the exercise of reasonable diligence) that the Diet Drug Recipient developed a matrix level condition or by Date 2. (Ex. P-3 at 61-63 of 148.) A class member who timely and properly exercises a back-end opt-out may pursue all of his or her settled claims against AHP and the AHP Released Parties except claims for punitive, multiple or exemplary damages, consumer fraud claims and medical monitoring claims. (Ex. P-3 at 61-63 of 148.) With respect to each class member who timely and properly exercises the back-end opt-out right and who initiates a lawsuit against AHP or any of the AHP Released Parties within one year from the date on which the back-end opt-out right is exercised, the AHP Released Parties shall not assert any defense based on any statute of limitations or repose, the doctrine of laches, any other defense predicated on the failure to timely pursue the claim, any defense based on "splitting" a cause of action, any defense based on a release signed pursuant to the Settlement Agreement and/or any other defense based on the existence of the Settlement Agreement. (Ex. P-3 at 61-63 of 148.)

[162]    Finally, the Settlement Agreement provides for a "financial insecurity opt-out right." (Ex. P-3 at 32-33 of 148.) If a condition of financial insecurity with respect to payment of AHP's obligations under the Settlement Agreement occurs in accordance with the conditions defined in the Agreement, then all Diet Drug Recipients who were diagnosed as having FDA Positive or Mild Mitral Regurgitation by the end of the Screening Period and who have registered for settlement benefits by Date 2 have a right to opt-out of the settlement and pursue all of their settled claims against AHP and the other Released Parties, including claims for punitive, multiple and exemplary damages. (Ex. P-3 at 32-33 of 148.)

[163]    3. Creation of a Settlement Trust

[164]    The Settlement Agreement requires the creation of a Settlement Trust which has responsibility for receiving the amounts deposited by AHP to fund the settlement, investing such amounts (under supervision of the court), administering the trust, providing the benefits contemplated by the Settlement Agreement and conducting the audits contemplated by the Settlement Agreement. *fn8 It is also required to issue regular reports to the court concerning these matters. (Ex. P-3 at 22-24, 73-81 & 100-15 of 148; Ex. P-4.) Pending the creation of the Trust, the functions of the Settlement Trust are to be performed by Interim Claims Administrators and an Interim Escrow Agent. (Ex. P-3 at 70-73 of 148.) On November 23, 1999, the Court appointed Gregory P. Miller, Esquire and the Honorable C. Judson Hamlin to serve as Interim Claims Administrators. Mr. Miller is an experienced trial lawyer who has served as Special Discovery Master in MDL 1203. Judge Hamlin served as a judge in the Superior Court of the State of New Jersey handling mass tort litigation until his retirement from that position in 1998. He has functioned as Special Settlement Master with respect to the Diet Drug Litigation pending in the state of New Jersey. (Tr. 5/9/00 at 18-20 & 54-56.) In Pretrial Order No. 1010, dated December 6, 1999, the court appointed PNC Bank to serve as Interim Escrow Agent.

[165]    The Settlement Agreement contemplates that there will be seven Trustees who will serve until the year 2005, and that, thereafter, there will be three Trustees for the Settlement Trust. (Ex. P-3 at 22 & 70 of 148.) By Pretrial Order No. 1159, the court appointed the following individuals to serve as Trustees for the Settlement Trust: Joseph L. Castle, II, Radnor, Pennsylvania; George A. Beller, M.D., Charlottesville, Virginia; Honorable Richard S. Cohen, New Brunswick, New Jersey; Senator Chris Harris, Arlington, Texas; Ms. Alison Overseth, New York, New York; Rose-Marie Robertson, M.D., FACC, Nashville, Tennessee; and Honorable Dean M. Trafelet, Chicago, Illinois. Although the court has issued an order appointing Trustees to the Settlement Trust, the Trust had not been formally organized as of the date of the Fairness Hearing. (Tr. 5/9/00 at 49.)

[166]    4. The Settlement Fund

[167]    The settlement requires the creation of two separate funds to provide benefits to class members. "Fund A" is intended to provide funding to pay for all non-matrix benefits available under the Settlement Agreement to class members and the associated costs of administering those benefits. "Fund B" is intended to provide funding to pay for matrix benefits for class members and the associated costs of administering those benefits.

[168]    Under the agreement, AHP is required to make payments into Fund A as follows: (1) $50 million 5 business days after preliminary approval; (2) $383 million 5 business days after trial court approval; (3)$383 million 180 days after the preceding payment of $383 million; and (4) $184 million 5 business days after Final Judicial Approval. (Ex. P-3 at 22-23 of 148.) With respect to Fund B, AHP agrees to have $2.55 billion available for Fund B payments which the Trustees may reasonably draw upon. (Ex. P-278 ¶ 4.) In any given quarter, to the extent that the $2.55 billion is not drawn upon, such amount accrues interest at one and a half percent per quarter or six percent a year, which carries forward to increase the available amount. Any remaining balance from Fund A is also included in Fund B. In addition, AHP receives credits against this amount for payments made to those who exercised an initial opt out right. These credits are capped at $300 million, which AHP cannot apply until year 5. (Ex. P-278 ¶ 33.) AHP also receives credits for payments made to those who exercise a back-end opt out right. The amount of both of these types of credits is the lesser of the payment AHP makes to the claimant or the matrix level for which such claimant would be entitled to under the Settlement.

[169]    Clearly, AHP has adequate financial coverage to meet these obligations. Dr. Rosen, who testified at the May 2000 proceedings and again on August 10, 2000, examined several AHP financial reports and statements and stated that AHP currently has approximately $2.6 billion in cash and marketable securities. (Tr. 8/10/00 at 107.) In addition, Dr. Rosen testified that AHP continues to generate better than half a billion dollars per quarter, or approximately $2.3 billion per year.

[170]    The court is also satisfied that Funds A and B are sufficient to provide the necessary benefits under the Settlement Agreement. To analyze the adequacy of the funding for Fund A and Fund B, the experts who testified at the Fairness Hearing relied on a number of considerations, including: (1) the number of potential class members; (2) the participation rate in the Settlement; (3) the proportion of participants who took fenfluramine and/or dexfenfluramine 61 days or more; (4) the proportion of participants who will be diagnosed to have FDA Positive levels of regurgitation; (5) the costs of providing echocardiograms within the Screening Program; (6) the cost of reimbursing certain echocardiograms; (7) administrative costs; (8) costs for the registry and research funds; (9) rates of possible progression to severe levels of regurgitation among class members with FDA Positive levels of regurgitation or mild mitral regurgitation; (10) progression among class members who will receive Matrix-level benefits to higher levels of the Matrix grid; and (11) the proportion of patients who have conditions entitling them to Matrix-level benefits who will receive benefits from the B Matrix rather than the A Matrix. (AHP Ex. 614 ¶¶ 9-16, 24, 26, 32-37; Ex. P-94 at 3-7.)

[171]    The experts used conservative assumptions likely to overstate the demands on Fund A and Fund B. Dr. McClellan (1) assumed a higher participation rate in the Settlement than has been seen to date; (2) assumed that a significantly higher proportion of class members who used the diet drugs for 61 days or longer would participate in the Settlement than would class members who used the drugs for 60 days or less; (3) did not take into account scientific evidence of regression of regurgitation in Diet Drug Recipients; (4) assumed higher prevalence rates of regurgitation than have been seen in Diet Drug Recipients; and (5) assumed progression to Matrix-level conditions despite the lack of evidence supporting appreciable progression among users of fenfluramine and dexfenfluramine. Dr. Kursh used similar assumptions. (AHP Ex. 614 ¶¶ 10, 16 & 32; Tr. 5/9/00 at 133-35; Ex. P-94 at 3-7.)

[172]    Employing these conservative assumptions, Dr. McClellan concluded that Fund A would not come close to exhaustion. Under Dr. McClellan's "base case," only $786 million of the $1 billion committed for Fund A would be used. (AHP Ex. 614 ¶ 25, Ex. C; Tr. 5/9/00 at 125.) The remaining funds would be available to pay for drug refunds to class members who used fenfluramine and/or dexfenfluramine for 61 days or longer and to reimburse class members for echocardiograms obtained outside the Screening Period. (Ex. P-32 at 2-3 of 13.)

[173]    With respect to Fund B, Dr. Kursh testified that, assuming a 100% participation rate in the settlement, the cost of paying matrix level benefits was $3.88 to 4.55 billion present value. (Tr. 8/10/00 at 97.) Dr. Kursh relied on previous analyses done by Drs. Karalis and Goodman, whose declarations were admitted at the Fairness hearing held in this court in May 2000. Dr. Rosen testified that $2.55 billion was a sufficient amount to cover all of the matrix claims likely to be filed in this Settlement. (Tr. 8/10/00 at 102.) Dr. Rosen relied on Dr. Kursh's testimony, the provisions in the Fourth Amendment to the Settlement Agreement, the prior declarations and analyses of Drs. Karalis and Goodman and a comparison of participation rates in other classes. Dr. Rosen concluded the payment structure contemplated under the Fourth Amendment would be sufficient to bear a 76%-90% participation rate. Dr. Rosen testified that prior to the Fourth Amendment, the amount provided under the Agreement was sufficient to bear 66%-79% participation. (Tr. 8/10/00 at 105-06.) Dr. Rosen also testified that, considering other classes in other cases, a participation rate of 30%-40% was considered a high participation rate. Id. (Tr. 8/10/00 at 105-06.)

[174]    No evidence was offered at the Fairness Hearing suggesting that the amounts to be paid into Fund A or Fund B are, or are likely to become, inadequate to pay for the benefits to be provided under the Settlement. No evidence was offered at the Fairness Hearing suggesting that the assumptions employed by the experts would understate the demands for benefits under the Settlement. Based on the methods and evaluations employed by these experts, the court is satisfied the amounts provided in Funds A and B are sufficient to provide all likely benefits under the Settlement Agreement.

[175]    5. Treatment of PPH Under the Settlement Agreement

[176]    Under the terms of the Settlement Agreement, PPH is defined as follows:

[177]    For a diagnosis based on examinations and clinical findings prior to death:

[178]    Mean pulmonary artery pressure by cardiac catheterization of > 25 medical monitoring Hg at rest or > 30 medical monitoring Hg with exercise with a normal pulmonary artery wedge pressure < 15 medical monitoring Hg; or

[179]    A peak systolic pulmonary artery pressure of > 60 medical monitoring Hg at rest measured by Doppler echocardiogram utilizing standard procedures; or Administration of Flolan to the patient based on a diagnosis of PPH with cardiac catheterization not done due to increased risk in the face of severe right heart dysfunction; and

[180]    Medical records which demonstrate that the following conditions have been excluded by the following results:

[181]    1.1.1.1.1Echocardiogram demonstrating no primary cardiac disease including, but not limited to, shunts, valvular disease (other than tricuspid or pulmonary valvular insufficiency as a result of PPH or trivial, clinically insignificant left- sided valvular regurgitation), and congenital heart disease (other than patent foramen ovale); and

[182]    1.1.1.1.2Left ventricular dysfunction defined as LVEF < 40% defined by MUGA, Echocardiogram or cardiac catheterization; and

[183]    1.1.1.1.3Pulmonary function tests demonstrating the absence of obstructive lung disease (FEV1/FVC > 50% of predicted) and the absence of greater than mild restrictive lung disease (total lung capacity > 60% of predicted at rest); and